THE BIG RETORT

The secret to living a longer life, or just a load of plonk? TheBigRetort pulls the cork... Scientists claim that sirtuins, proteins, become increasingly important as people age. It is these proteins that ensure which genes should be “off” - and thereby remain silent as the ageing process continues. Paradoxically it is these same proteins that are believed to repair DNA damage as we age. The critical protein controls which genes are off and on as well as overseeing DNA repair - and there’s the rub. As we age, chromosomes get damaged and the SIR1 proteins are finally overwhelmed. It is this activity that leads to the process of aging, not time itself which moves on inexorably, unconcerned by birthdays and mankind his or herself. But can the aging process itself be slowed? Scientists are beginning to suspect so; mice with more SIRT1 proteins have the improved ability to repair their DNA and prevent the unwanted changes in genes. Resveratrol extended the lifespan in mice by 24 to 46 perc...

A controversial experiment is planned to take place tomorrow that may signal THE END of the Earth. But could experiments like the controversial Large Hadron Collider (LHC) already have taken place? TheBigRetort investigates...and discovers that someone may have got the 'maths' wrong. The LHC Safety Study Group studied the safety of the forthcoming experiment in 2003. It concluded that the planned experiments—there are a number of them--presented no danger. The group focused on two phenomena, namely the possible production of microscopic black holes, the sort that suck you in and blow you out and create additional dimensions of space, which way is up?- and also postulated other exotic phenomena - the possible production of ‘strangelets', hypothetical pieces of matter. The LHC will reproduce, in the laboratory and under controlled conditions, collisions at centre-of-mass energies less than those reached in the atmosphere by some of the cosmic rays that have been bombardin...

Recently we delivered a startling account of the major failings of Eastbourne District General Hospital and its 'aftercare' treatment... of a dead man. Michael Morgan, 51, died in December last and was swiftly cremated on the instruction of hospital officials at 'EDGH': but without the family's knowledge. Following which, they asked for the ashes. Not much to ask given the circumstances one might think, however... it was a request that met with silence. Now, finally, the family has received a response, and it looks as if someone may have removed one of the branches of its family tree. An exclusive from TheBigRetort In "Michael's Ashes" we highlighted the failings of East Sussex NHS Trust and its 'dead patient aftercare'... which was found to be a bit wanting . When Michael Morgan died and his family discovered the death and cremation (nearly three months later and only via a chance encounter) Kim Hodgson, chief executive of East Sussex Trust, i...

As the child of a black man and white woman Barack Obama is often (simply) referred to as 'black'. A description that will one day serve to display a time of ignorance - because Barack Obama is much much more. "There is not a black America and a white America and Latino America and Asian America - there's the United States of America," Obama once wrote. However, note in the above paragraph from his book The Audacity of Hope that there is no capital letter on black and white. In fact, neither is a nation, and neither is a culture. Obama, born between the two, has already made the journey and knows this. And, although many in the US have leaned heavily on 'skin' difference for quite some time this presidential candidate - if elected - would help a young nation recognise that any 'difference' between them is countered by that which unites: America. Meanwhile, in 2008, a fledgling nation stands at the crossroads. A presidential candidate, b...

Around the globe the words 'domain' and 'cash parking' are synonymous with GoDaddy. So why are 70% of the reviews on the first page of Google so negative? TheBigRetort investigates... and finds the odd Bob or two. (Pictured left, Bob Parsnips, founder GoDaddy.) Google GoDaddy along with Cashparking and it quickly becomes evident that all is not well in Elsinore. (That's Denmark for all our American readers.) Indeed... the praise once heaped on the largest domain name registrar in the world has now turned to opprobrium. There is a pestilence in the land and many a brave knight quickly stirs abroad, to other domains. (Oops. We quote a writer of plays born over here.) What we mean is, here's just one of many critiques... "I like GoDaddy.com and I admire Bob Parsons, his 'bigger than life' personality and panache reflecting on GoDaddy, so it’s not personal, it’s business," one disgruntled critic wrote. He had invested in the GoDaddy C...

GoDaddy is the largest domain name registrar in the 'electric universe'. During the final six months of 2005 approximately one-third of all domain names (the top five) were registered via this registrar. By the end of May 2006, it managed approximately 14.2 million domain names. As a 'best-of-breed' it is also North America’s largest shared website hosting provider. But when TheBigRetort tried to put a series of questions to its founder it met with a wall of silence - unusual considering its founder's usual retort: "If GoDaddy.com is anything, it is an outspoken company and I am an outspoken CEO." So why was Daddy being so evasive? First, a bit of blurb on founder B-o-b P-a-r-s-o-n-s. Robert Parsons is the CEO and Chairman of GoDaddy. Prior to founding the company in 1997, he also founded Parsons technology. Bob and his then wife grew the software company out a basement kitchen. A decade later the pair sold it for many millions of dollars. Retirement did ...

TheBigRetort can reveal that a recent allergic epidemic that has been studied in Lahti, Finland, has found that being a dog - or a couch potato for that matter -may seriously damage your health. In fact, if that sofa has been made in China reclining in front of the telly may not be so 'suite'. A Finnish study into the background to a recent epidemic that stretched the length and breadth of Britain has identified the substance that has caused agonising suffering in thousands of people. Chinese-made settees sold by Argos and Land of Leather have been named as the culprits of a violent irritant-related eczema, blisters, weeping and cracking. After studying five patients the Finnish study concluded that the allergies related to a newly purchased chair or sofa. Furniture samples were analysed and compounds identified using a mass spectrum library and measured. The patients showed strong reactions to upholstery fabric samples and to dimethylfumarate, 'down to a level of 1 p.p.m....